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Spermidine enhances autophagy, which helps cells remove damaged components and regenerate, maintaining cellular function and vitality.
By activating pathways associated with longevity, spermidine can potentially extend lifespan and improve health-span, the period of life spent in good health.
Spermidine supports brain health by reducing oxidative stress and promoting autophagy in neural cells, which may enhance memory and cognitive performance.
Spermidine has anti-inflammatory properties, helping to lower chronic inflammation that is linked to various age-related diseases.
By promoting autophagy and reducing oxidative stress, spermidine supports the health of the cardiovascular system, potentially lowering the risk of heart disease.
Spermidine can improve the condition of hair and skin by promoting cellular regeneration and reducing oxidative damage, contributing to a more youthful appearance.
When spermidine is ingested through supplements or diet, it is absorbed in the intestines and enters the bloodstream. From there, it is transported to various tissues and cells throughout the body. Spermidine is taken up by cells where it can exert its biological effects, penetrating cellular membranes to reach intracellular targets.
Inside the cells, spermidine promotes autophagy by inhibiting key molecular pathways that normally suppress this process, such as the mTOR (mechanistic target of rapamycin) pathway. Autophagy is a critical cellular housekeeping mechanism where cells degrade and recycle damaged organelles, misfolded proteins, and other cellular debris. By enhancing autophagy, spermidine helps maintain cellular homeostasis, reduce oxidative stress, and improve overall cellular function.
Spermidine influences the expression of genes associated with cellular stress resistance and longevity. It activates transcription factors and signaling pathways that enhance the cell's ability to cope with stress and prevent damage. This regulation of gene expression helps improve cellular health, supports longevity, and contributes to the overall anti-aging effects of spermidine. By maintaining cellular integrity and promoting regeneration, spermidine supports healthy aging and the prevention of age-related diseases.
